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Dokumenttyp:
Article
Autor(en):
Raeth, Christoph; Baum, Thomas; Monetti, Roberto; Sidorenko, Irina; Wolf, Petra; Eckstein, Felix; Matsuura, Maiko; Lochmueller, Eva-Maria; Zysset, Philippe K.; Rummeny, Ernst J.; Link, Thomas M.; Bauer, Jan S.
Titel:
Scaling relations between trabecular bone volume fraction and microstructure at different skeletal sites
Abstract:
In this study, we investigated the scaling relations between trabecular bone volume fraction (BV / TV) and parameters of the trabecular microstructure at different skeletal sites. Cylindrical bone samples with a diameter of 8 mm were harvested from different skeletal sites of 154 human donors in vitro: 87 from the distal radius, 59/69 from the thoracic/lumbar spine, 51 from the femoral neck, and 83 from the greater trochanter. mu CT images were obtained with an isotropic spatial resolution of 26 pm. BV / TV and trabecular microstructure parameters (TbN, TbTh, TbSp, scaling indices (< > and sigma of alpha and alpha(z)), and Minkowski Functionals (Surface, Curvature, Euler)) were computed for each sample. The regression coefficient beta was determined for each skeletal site as the slope of a linear fit in the double-logarithmic representations of the correlations of By / TV versus the respective microstructure parameter. Statistically significant correlation coefficients ranging from r = 0.36 to r = 0.97 were observed for BV / TV versus microstructure parameters, except for Curvature and Euler. The regression coefficients beta were 0.19 to 0.23 (TbN), 021 to 030 (TbTh), -0.28 to -0.24 (TbSp), 0.58 to 0.71 (Surface) and 0.12 to 0.16 (), 0.07 to 0.11 (), -0.44 to -030 (sigma(alpha)), and -0.39 to -0.14 (sigma(alpha(z))) at the different skeletal sites. The 95% confidence intervals of 13 overlapped for almost all microstructure parameters at the different skeletal sites. The scaling relations were independent of vertebral fracture status and similar for subjects aged 60-69, 70-79, and >79 years. In conclusion, the bone volume fraction-microstructure scaling relations showed a rather universal character. (C) 2013 Elsevier Inc. All rights reserved.
Stichworte:
Micro-CT; Bone volume fraction; Trabecular bone microstructure; Scaling relations; Wolffs law
Zeitschriftentitel:
Bone
Jahr:
2013
Band / Volume:
57
Monat:
DEC
Heft / Issue:
2
Seitenangaben Beitrag:
377-383
Sprache:
English
Volltext / DOI:
doi:10.1016/j.bone.2013.09.004
Verlag / Institution:
ELSEVIER SCIENCE INC
Print-ISSN:
8756-3282
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