User: Guest  Login
Document type:
Zeitschriftenaufsatz 
Author(s):
Xiao, Yan; Hoodless, Laura J; Petrucco, Luigi; Portugues, Ruben; Czopka, Tim 
Title:
Oligodendrocyte Precursor Cells Sculpt the Visual System by Regulating Axonal Remodeling 
Abstract:
Many oligodendrocyte precursor cells (OPCs) do not differentiate to form myelin, suggesting additional roles of this cell population. The zebrafish optic tectum contains OPCs in regions devoid of myelin. Elimination of these OPCs impaired precise control of retinal ganglion cell axon arbor size during formation and maturation of retinotectal connectivity, and in consequence impaired visual acuity. Therefore, OPCs fine-tune neural circuit structure and function independently of their canonical ro...    »
 
Journal title:
bioRxiv 
Year:
2021 
Publisher:
Cold Spring Harbor Laboratory