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- Title:
Scaling relations between trabecular bone volume fraction and microstructure at different skeletal sites
- Document type:
- Article
- Author(s):
- Raeth, Christoph; Baum, Thomas; Monetti, Roberto; Sidorenko, Irina; Wolf, Petra; Eckstein, Felix; Matsuura, Maiko; Lochmueller, Eva-Maria; Zysset, Philippe K.; Rummeny, Ernst J.; Link, Thomas M.; Bauer, Jan S.
- Abstract:
- In this study, we investigated the scaling relations between trabecular
bone volume fraction (BV / TV) and parameters of the trabecular
microstructure at different skeletal sites.
Cylindrical bone samples with a diameter of 8 mm were harvested from
different skeletal sites of 154 human donors in vitro: 87 from the
distal radius, 59/69 from the thoracic/lumbar spine, 51 from the femoral
neck, and 83 from the greater trochanter. mu CT images were obtained
with an isotropic spatial resolution of 26 pm. BV / TV and trabecular
microstructure parameters (TbN, TbTh, TbSp, scaling indices (< > and
sigma of alpha and alpha(z)), and Minkowski Functionals (Surface,
Curvature, Euler)) were computed for each sample. The regression
coefficient beta was determined for each skeletal site as the slope of a
linear fit in the double-logarithmic representations of the correlations
of By / TV versus the respective microstructure parameter.
Statistically significant correlation coefficients ranging from r = 0.36
to r = 0.97 were observed for BV / TV versus microstructure parameters,
except for Curvature and Euler. The regression coefficients beta were
0.19 to 0.23 (TbN), 021 to 030 (TbTh), -0.28 to -0.24 (TbSp), 0.58 to
0.71 (Surface) and 0.12 to 0.16 (
), 0.07 to 0.11 ( - Keywords:
- Micro-CT; Bone volume fraction; Trabecular bone microstructure; Scaling relations; Wolffs law
- Journal title:
- Bone
- Year:
- 2013
- Journal volume:
- 57
- Month:
- DEC
- Journal issue:
- 2
- Pages contribution:
- 377-383
- Language:
- English
- Fulltext / DOI:
- doi:10.1016/j.bone.2013.09.004
- Publisher:
- ELSEVIER SCIENCE INC
- Print-ISSN:
- 8756-3282
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