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Document type:
Zeitschriftenaufsatz
Author(s):
Keskin, A.; Kekus, M.; Adelsberger, H.; Neumann, U.; Shimshek, D.; Song, B.; Zott, B.; Peng, T.; Foerstl, H.; Staufenbiel, M.; Nelken, I.; Sakmann, B.; Konnerth, A.; Busche, M.
Title:
BACE inhibition-dependent repair of Alzheimer ́s pathophysiology
Abstract:
Amyloid-β (Aβ) is thought to play an essential pathogenic role in Alzheimer ́s disease (AD). A key enzyme involved in the generation of Aβ is the β-secretase BACE for which powerful inhibitors, already used in human clinical trials, have recently been developed. However, although BACE inhibition can reduce cerebral Aβ levels, it remains unclear whether it can also ameliorate neural circuit and memory impairments. By employing histochemistry, in vivo Ca2+-imaging and behavioral analyses in a mous...     »
Keywords:
CAMP,PNAS,MicroscopicImageAnalysis
Year:
2017
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