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- Title:
Classification and pathology of gastroenteropancreatic neuroendocrine neoplasms.
- Document type:
- Journal Article
- Author(s):
- Klöppel, G
- Abstract:
- Gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs) are composed of cells with a neuroendocrine phenotype. The old and the new WHO classifications distinguish between well-differentiated and poorly differentiated neoplasms. All well-differentiated neoplasms, regardless of whether they behave benignly or develop metastases, will be called neuroendocrine tumours (NETs), and graded G1 (Ki67 <2%) or G2 (Ki67 2-20%). All poorly differentiated neoplasms will be termed neuroendocrine carcinomas (NECs) and graded G3 (Ki67 >20%). To stratify the GEP-NETs and GEP-NECs regarding their prognosis, they are now further classified according to TNM-stage systems that were recently proposed by the European Neuroendocrine Tumour Society (ENETS) and the AJCC/UICC. In the light of these criteria the pathology and biology of the various NETs and NECs of the gastrointestinal tract (including the oesophagus) and the pancreas are reviewed.
- Journal title abbreviation:
- Endocr Relat Cancer
- Year:
- 2011
- Journal volume:
- 18 Suppl 1
- Pages contribution:
- S1-S16
- Language:
- eng
- Fulltext / DOI:
- doi:10.1530/ERC-11-0013
- Pubmed ID:
- http://view.ncbi.nlm.nih.gov/pubmed/22005112
- Print-ISSN:
- 1351-0088
- TUM Institution:
- Institut für Allgemeine Pathologie und Pathologische Anatomie
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