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Dokumenttyp:
Journal Article
Autor(en):
Conrad, David; Kehl, Alexandra; Beitzinger, Christoph; Metzler, Thomas; Steiger, Katja; Pfarr, Nicole; Fischer, Konrad; Klopfleisch, Robert; Aupperle-Lellbach, Heike
Titel:
Molecular Genetic Investigation of Digital Melanoma in Dogs.
Abstract:
Canine digital melanoma, in contrast to canine oral melanoma, is still largely unexplored at the molecular genetic level. The aim of this study was to detect mutant genes in digital melanoma. Paraffin-embedded samples from 86 canine digital melanomas were examined for the BRAF V595E variant by digital droplet PCR (ddPCR), and for exon 11 mutations in c-kit. Furthermore, exons 2 and 3 of KRAS and NRAS were analysed by Sanger sequencing. Copy number variations (CNV) of KITLG in genomic DNA were an...     »
Zeitschriftentitel:
Vet Sci
Jahr:
2022
Band / Volume:
9
Heft / Issue:
2
Volltext / DOI:
doi:10.3390/vetsci9020056
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/35202309
TUM Einrichtung:
Institut für Allgemeine Pathologie und Pathologische Anatomie
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