Interventional Real-Time Quantification of 90Y-Microspheres Distribution in Selective Internal Radiotherapy

Selective internal radiotherapy (SIRT) is a treatment option for disseminated malignant liver lesions. Further optimization in patient's outcome might be achievable by highly selective dose implantation and/or tumor-orientated dose escalation. We propose a new workflow for real-time quantification of the 90Y-microspheres distribution. The methodology is based on planar 90Y-Bremsstrahlung imaging and is intended for future online monitoring during angiographic application. Emission data are compared against Monte Carlo (MC) simulated data representing predefined 90Y-accumulation pattern. We present two cases demonstrating the proposed workflow. We conclude that rapid in-silico quantification of intra-hepatic 90Y accumulation pattern from planar Bremsstrahlung imaging is feasible by a MC based framework. Activity quantification in large volumes is more precise than in small volumes. Potentially, scatter and anisotropic Bremsstrahlung generation degrade simulation results. MC framework will be refined and tested accordingly.     «

Selective internal radiotherapy (SIRT) is a treatment option for disseminated malignant liver lesions. Further optimization in patient's outcome might be achievable by highly selective dose implantation and/or tumor-orientated dose escalation. We propose a new workflow for real-time quantification of the 90Y-microspheres distribution. The methodology is based on planar 90Y-Bremsstrahlung imaging and is intended for future online monitoring during angiographic application. Emission data are compa...     »