Cancer cachexia is a multifactorial metabolic syndrome characterized by energy-wasting, increased systemic inflammation, and metabolic dysfunctions, leading to muscle and fat mass deterioration. Energy and lipid metabolism is altered, and maintaining adipose tissue mass is hypothesized to be an effective treatment strategy against cancer cachexia. Three compounds selected from the lipolysis assay-based compound screening affected specific cachexia-related molecular pathways in vivo. However, they did not ameliorate the weight and tissue loss in the C26 cachexia model.
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Cancer cachexia is a multifactorial metabolic syndrome characterized by energy-wasting, increased systemic inflammation, and metabolic dysfunctions, leading to muscle and fat mass deterioration. Energy and lipid metabolism is altered, and maintaining adipose tissue mass is hypothesized to be an effective treatment strategy against cancer cachexia. Three compounds selected from the lipolysis assay-based compound screening affected specific cachexia-related molecular pathways in vivo. However, the...
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