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Original title:
Novel Bi- and Trifunctional Inhibitors of Tumor-associated Proteolytic Systems
Translated title:
Neue Bi- und Trifunktionelle Inhibitoren von Tumorassoziierten Proteolytischen Systemen
Author:
Krol, Janna
Year:
2004
Document type:
Dissertation
Faculty/School:
Fakultät für Medizin
Advisor:
Magdolen, V. (Priv.-Doz. Dr.)
Referee:
Magdolen, V. (Priv.-Doz. Dr.); Graeff, H. (Univ.-Prof. Dr. em); Peschel, C. (Univ.-Prof. Dr.)
Format:
Text
Language:
en
Subject group:
MED Medizin
Keywords:
tumor-invasion; metastasis; ovarian cancer; matrixmetalloproteinases; uPA; cysteine proteases
Translated keywords:
tumorinvasion; metastasierung; ovarialkarzinom; matrixmetalloproteinasen; uPA; cysteinproteasen
Abstract:
Several proteases including matrix metalloproteinases (MMPs), cysteine proteases (CPs), and serine proteases (e.g. the uPA/plasmin system) are involved in cancer cell invasion and metastasis. In the present study we designed multifunctional inhibitors that efficiently inhibit the enzymatic activity of MMPs, CPs and uPA/uPA-receptor interaction. Recombinant inhibitors were at first produced in E. coli expression system and characterized in vitro. Inoculation of the ovarian cancer cells expressing...     »
Translated abstract:
Tumorzell-Invasion und Metastasierung werden u.a. durch verschiedene Proteasen, wie z.B. Matrixmetalloproteinasen (MMPs), Serinproteasen (u.a. der Urokinae-Typ Plasminogen Aktivator; uPA) und Cysteinproteasen (CPs), vermittelt. In dieser Arbeit wurden multifunktionelle Inhibitoren entwickelt, die in der Lage sind, MMPs, CPs und die uPA/uPA-Rezeptor Interaktion effizient zu inhibieren. Die Inhibitoren wurden zunächst in einem E. coli-Expressionssystem rekombinant produziert und in vitro charakte...     »
Publication :
Universitätsbibliothek der TU München
WWW:
https://mediatum.ub.tum.de/?id=602419
Date of submission:
24.09.2003
Oral examination:
02.07.2004
File size:
1523890 bytes
Pages:
89
Urn (citeable URL):
https://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:91-diss2004070204497
Last change:
27.06.2005
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