The first Part of the thesis deals with the development of new concepts for the synthesis of hetero- and carbocycles. Starting materials for the reactions were alkynes , which could be activated either by π acids or by electrophiles for domino-cyclisaton-reactions. We were able to synthesise complex carbocycles by direct carbocyclization of aldehydes with alkynes: combining gold catalysis with aminocatalysis. Further we could synthesis highly substituted furanones utilizing a electrophile-Induced or a transition-metal-catalyzed tandem cyclization/1,2-migration reaction. Also we were able to access cyclopentenaldehydes, cyclohexenester, cyclohexenfluorids, cyclohexadiens, iodoaromats, and tricyclic aziridines by cycloisomerisation of 1,5-enines.
The second part of the thesis deals with the synthesis of the polyol-fragment of Marinomycin A and some attempts to synthesise the macrolacton Marinomycin A.
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The first Part of the thesis deals with the development of new concepts for the synthesis of hetero- and carbocycles. Starting materials for the reactions were alkynes , which could be activated either by π acids or by electrophiles for domino-cyclisaton-reactions. We were able to synthesise complex carbocycles by direct carbocyclization of aldehydes with alkynes: combining gold catalysis with aminocatalysis. Further we could synthesis highly substituted furanones utilizing a electrophile-Induce...
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