In a prospective, monocentric and controlled trial with grass pollen allergic children we could prove the efficacy of a pre-seasonal specific immunotherapy over three years. It was performed with seven to ten subcutaneous injections per year of the depot allergoid Allergovit. The trial shows a significant decrease of allergic symptoms and a reduction of anti-allergic medication leading to improvement of the children´s quality of life. The above described clinical improvement is assessed in a symptom-medication-score, developed by ourselves. The improvement of the symptom-medication-score is compared with the reduction of the skin reactivity in a prick test as well as with the significant change of the levels of the allergen-specific immunoglobulines IgE (decrease), IgG1 and IgG4 (increase).
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In a prospective, monocentric and controlled trial with grass pollen allergic children we could prove the efficacy of a pre-seasonal specific immunotherapy over three years. It was performed with seven to ten subcutaneous injections per year of the depot allergoid Allergovit. The trial shows a significant decrease of allergic symptoms and a reduction of anti-allergic medication leading to improvement of the children´s quality of life. The above described clinical improvement is assessed in a sym...
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