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Titel:

HDAC2 mediates therapeutic resistance of pancreatic cancer cells via the BH3-only protein NOXA.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Fritsche, P; Seidler, B; Schüler, S; Schnieke, A; Göttlicher, M; Schmid, RM; Saur, D; Schneider, G
Abstract:
BACKGROUND: Although histone deacetylase inhibitors (HDACi) are promising cancer therapeutics regulating proliferation, differentiation and apoptosis, molecular pathways engaged by specific HDAC isoenzymes in cancer are ill defined. RESULTS: In this study we demonstrate that HDAC2 is highly expressed in pancreatic ductal adenocarcinoma (PDAC), especially in undifferentiated tumours. We show that HDAC2, but not HDAC1, confers resistance towards the topoisomerase II inhibitor etoposide in PDAC cel...     »
Zeitschriftentitel:
Gut
Jahr:
2009
Band / Volume:
58
Heft / Issue:
10
Seitenangaben Beitrag:
1399-409
Sprache:
eng
Volltext / DOI:
doi:10.1136/gut.2009.180711
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/19528037
Print-ISSN:
0017-5749
TUM Einrichtung:
II. Medizinische Klinik und Poliklinik (Gastroenterologie); Institut für Toxikologie und Umwelthygiene
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