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Title:

Activin tunes GABAergic neurotransmission and modulates anxiety-like behavior.

Document type:
Journal Article; Research Support, Non-U.S. Gov't; Comparative Study; In Vitro
Author(s):
Zheng, F; Adelsberger, H; Müller, MR; Fritschy, JM; Werner, S; Alzheimer, C
Abstract:
Activin, a member of the transforming growth factor-beta superfamily, affords neuroprotection in acute brain injury, but its physiological functions in normal adult brain are largely unknown. Using transgenic (tg) mice expressing a dominant-negative activin receptor mutant under the control of the CaMKIIalpha promoter in forebrain neurons, we identified activin as a key regulator of gamma-aminobutyric acid (GABA)ergic synapses and anxiety-like behavior. In the open field, wild-type (wt) and tg m...     »
Journal title abbreviation:
Mol Psychiatry
Year:
2009
Journal volume:
14
Journal issue:
3
Pages contribution:
332-46
Language:
eng
Fulltext / DOI:
doi:10.1038/sj.mp.4002131
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/18180762
Print-ISSN:
1359-4184
TUM Institution:
Institut für Neurowissenschaften
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