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Titel:

Cyclic GMP kinase and RhoA Ser188 phosphorylation integrate pro- and antifibrotic signals in blood vessels.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't; Article
Autor(en):
Sawada, N; Itoh, H; Miyashita, K; Tsujimoto, H; Sone, M; Yamahara, K; Arany, ZP; Hofmann, F; Nakao, K
Abstract:
Vascular fibrosis is a major complication of hypertension and atherosclerosis, yet it is largely untreatable. Natriuretic peptides (NPs) repress fibrogenic activation of vascular smooth muscle cells (VSMCs), but the intracellular mechanism mediating this effect remains undetermined. Here we show that inhibition of RhoA through phosphorylation at Ser188, the site targeted by the NP effector cyclic GMP (cGMP)-dependent protein kinase I (cGK I), is critical to fully exert antifibrotic potential. cG...     »
Zeitschriftentitel:
Mol Cell Biol
Jahr:
2009
Band / Volume:
29
Heft / Issue:
22
Seitenangaben Beitrag:
6018-32
Sprache:
eng
Volltext / DOI:
doi:10.1128/MCB.00225-09
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/19737918
Print-ISSN:
0270-7306
TUM Einrichtung:
Institut für Pharmakologie und Toxikologie
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