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Titel:

Regulatory allospecific T cell clones abrogate chronic allograft rejection.

Dokumenttyp:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Autor(en):
Waaga-Gasser, AM; Grimm, MR; Lutz, J; Lange, V; Lenhard, SM; Aviles, B; Kist-van Holthe, JE; Lebedeva, T; Samsonov, D; Meyer, D; Hancock, WW; Heemann, U; Gasser, M; Chandraker, A
Abstract:
True alloantigen-specific tolerance is the ultimate goal of solid organ transplantation, eliminating the need for long-term immunosuppression. Recent evidence suggests that Th1-derived cytokines are associated with rejection and Th2-derived cytokines with long-term allograft survival, but the roles of these subsets in rejection and tolerance are incompletely understood. Here, we analyzed the functional and regulatory capacities of T cell clones derived from tolerant and rejecting rats (Wistar ra...     »
Zeitschriftentitel:
J Am Soc Nephrol
Jahr:
2009
Band / Volume:
20
Heft / Issue:
4
Seitenangaben Beitrag:
820-30
Sprache:
eng
Volltext / DOI:
doi:10.1681/ASN.2008020164
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/19297560
Print-ISSN:
1046-6673
TUM Einrichtung:
Fachgebiet Nephrologie (Prof. Heemann)
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