Variants in ZFHX3 are associated with atrial fibrillation in individuals of European ancestry.

Benjamin, EJ; Rice, KM; Arking, DE; Pfeufer, A; van Noord, C; Smith, AV; Schnabel, RB; Bis, JC; Boerwinkle, E; Sinner, MF; Dehghan, A; Lubitz, SA; D'Agostino, RB; Lumley, T; Ehret, GB; Heeringa, J; Aspelund, T; Newton-Cheh, C; Larson, MG; Marciante, KD; Soliman, EZ; Rivadeneira, F; Wang, TJ; Eiriksdottir, G; Levy, D; Psaty, BM; Li, M; Chamberlain, AM; Hofman, A; Vasan, RS; Harris, TB; Rotter, JI; Kao, WH; Agarwal, SK; Stricker, BH; Wang, K; Launer, LJ; Smith, NL; Chakravarti, A; Uitterlinden, AG; Wolf, PA; Sotoodehnia, N; Köttgen, A; van Duijn, CM; Meitinger, T; Mueller, M; Perz, S; Steinbeck, G; Wichmann, HE; Lunetta, KL; Heckbert, SR; Gudnason, V; Alonso, A; Kääb, S; Ellinor, PT; Witteman, JC     «

Benjamin, EJ; Rice, KM; Arking, DE; Pfeufer, A; van Noord, C; Smith, AV; Schnabel, RB; Bis, JC; Boerwinkle, E; Sinner, MF; Dehghan, A; Lubitz, SA; D'Agostino, RB; Lumley, T; Ehret, GB; Heeringa, J; Aspelund, T; Newton-Cheh, C; Larson, MG; Marciante, KD; Soliman, EZ; Rivadeneira, F; Wang, TJ; Eiriksdottir, G; Levy, D; Psaty, BM; Li, M; Chamberlain, AM; Hofman, A; Vasan, RS; Harris, TB; Rotter, JI; Kao, WH; Agarwal, SK; Stricker, BH; Wang, K; Launer, LJ; Smith, NL; Chakravarti, A; Uitterlinden, AG...     »

We conducted meta-analyses of genome-wide association studies for atrial fibrillation (AF) in participants from five community-based cohorts. Meta-analyses of 896 prevalent (15,768 referents) and 2,517 incident (21,337 referents) AF cases identified a new locus for AF (ZFHX3, rs2106261, risk ratio RR = 1.19; P = 2.3 x 10(-7)). We replicated this association in an independent cohort from the German AF Network (odds ratio = 1.44; P = 1.6 x 10(-11); combined RR = 1.25; combined P = 1.8 x 10(-15)).     «

We conducted meta-analyses of genome-wide association studies for atrial fibrillation (AF) in participants from five community-based cohorts. Meta-analyses of 896 prevalent (15,768 referents) and 2,517 incident (21,337 referents) AF cases identified a new locus for AF (ZFHX3, rs2106261, risk ratio RR = 1.19; P = 2.3 x 10(-7)). We replicated this association in an independent cohort from the German AF Network (odds ratio = 1.44; P = 1.6 x 10(-11); combined RR = 1.25; combined P = 1.8 x 10(-15...     »