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- Titel:
The proline 12 alanine substitution in the PPARgamma2 gene is associated with increased extent of coronary artery disease in men.
- Dokumenttyp:
- Journal Article
- Autor(en):
- Schneider, JG; Schiekofer, S; Eynatten, M; Schlimmer, P; Dugi, KA
- Abstract:
- OBJECTIVE: To determine whether there is an independent association between the Pro12Ala polymorphism in the peroxisome proliferator-activated-receptor gamma2 (PPARgamma2)-gene and the extent of coronary artery disease in men. RESEARCH DESIGN AND METHODS: We determined the Pro12Ala polymorphism in the PPARgamma2 gene in 240 male patients undergoing elective coronary angiograpy, and quantitated the degree of CAD by evaluating the extent-score which better correlates with known risk factors than other measures of CAD. RESULTS: The presence of the 12Ala allele was significantly associated with higher CAD extent (r=0.27, p<0.01). CAD extent was also correlated with the extent of insulin resistance (HOMA, r=0.22, p<0.01), and age (r=0.16, p<0.05). Multivariate analysis revealed an independent association between the 12Ala allele PPARgamma2 with extent-score (beta=0.32, p<0.01). CONCLUSIONS: The 12Ala allele in PPARgamma2 correlates with a significantly increased CAD extent in men, which suggest that lower activity of the transcription factor PPARgamma2 is associated with more severe CAD.
- Zeitschriftentitel:
- Exp Clin Endocrinol Diabetes
- Jahr:
- 2009
- Band / Volume:
- 117
- Heft / Issue:
- 9
- Seitenangaben Beitrag:
- 519-21
- Sprache:
- eng
- Volltext / DOI:
- doi:10.1055/s-0029-1216351
- PubMed:
- http://view.ncbi.nlm.nih.gov/pubmed/19536733
- Print-ISSN:
- 0947-7349
- TUM Einrichtung:
- Fachgebiet Nephrologie (Prof. Heemann)
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