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Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Schön, U; Diem, O; Leitner, L; Günzburg, WH; Mager, DL; Salmons, B; Leib-Mösch, C
Title:
Human endogenous retroviral long terminal repeat sequences as cell type-specific promoters in retroviral vectors.
Abstract:
The human genome contains more than half a million human endogenous retrovirus (HERV) long terminal repeats (LTRs) that can be regarded as mobile regulatory modules. Many of these HERV LTRs have been recruited during evolution as transcriptional control elements for cellular gene expression. We have cloned LTR sequences from two HERV families, HERV-H and HERV-L, differing widely in their activity and tissue specificity into a murine leukemia virus (MLV)-based promoter conversion vector (ProCon)....     »
Journal title abbreviation:
J Virol
Year:
2009
Journal volume:
83
Journal issue:
23
Pages contribution:
12643-50
Language:
eng
Fulltext / DOI:
doi:10.1128/JVI.00858-09
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/19741000
Print-ISSN:
0022-538X
TUM Institution:
Institut für Virologie
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