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Title:

Conduits mediate transport of low-molecular-weight antigen to lymph node follicles.

Document type:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Author(s):
Roozendaal, R; Mempel, TR; Pitcher, LA; Gonzalez, SF; Verschoor, A; Mebius, RE; von Andrian, UH; Carroll, MC
Abstract:
To track drainage of lymph-borne small and large antigens (Ags) into the peripheral lymph nodes and subsequent encounter by B cells and follicular dendritic cells, we used the approach of multiphoton intravital microscopy. We find a system of conduits that extend into the follicles and mediate delivery of small antigens to cognate B cells and follicular dendritic cells. The follicular conduits provide an efficient and rapid mechanism for delivery of small antigens and chemokines such as CXCL13 t...     »
Journal title abbreviation:
Immunity
Year:
2009
Journal volume:
30
Journal issue:
2
Pages contribution:
264-76
Language:
eng
Fulltext / DOI:
doi:10.1016/j.immuni.2008.12.014
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/19185517
Print-ISSN:
1074-7613
TUM Institution:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene
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