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Original title:
Untersuchung der Einflussgrößen echokardiographischer Veränderungen der Herzklappen bei mit Cabergolin behandelten Patienten mit Parkinsonsyndromen - eine mono-zentrische, single-rater Studie mit prospektivem Arm und Querschnittsarm
Translated title:
A study of the variables to influence echocardiographic parameters in Parkinson patients treated with cabergoline - a mono-rater, single-center survey with a prospective and a cross-sectional cohort
Author:
Riedl, Lina
Year:
2010
Document type:
Dissertation
Faculty/School:
Fakultät für Medizin
Advisor:
Fietzek, Urban M. (Dr.)
Referee:
Ceballos-Baumann, Andres O. (Prof. Dr.)
Language:
de
Subject group:
MED Medizin
Keywords:
Parkinson, Herzklappen, Cabergolin
Translated keywords:
Parkinson, valvular heart disease, cabergoline
Abstract:
Die vorliegende Arbeit betrachtet den Zusammenhang zwischen der Einnahme des Dopamin- und Serotoninagonisten Cabergolin auf Funktion des Endokards. Wichtigste Ergebnisse sind die Darstellung des Risikofaktors arterieller Hypertonus für das Auftreten einer Aorteninsuffizienz, die Abhängigkeit des Vorhandenseins einer mäßigen Trikuspidalinsuffizienz vom Alter sowie der Kumulativdosis und der Nachweis einer funktionellen Remission der Aorteninsuffizienz nach Stop der Cabergolinexposition. Es wurde...     »
Translated abstract:
Background: Treatment of Parkinson’s disease (PD) with ergot-derived dopamine agonists (edDA) can lead to valvular heart disease (VHD). Method: We conducted (i) a cross sectional transthoracic echocardiographic (TTE) survey in 93 PD patients, and (ii) prospectively assessed 24 patients under cabergoline treatment to (i) assess risk factors and (ii) follow-up on the course of valvular regurgitation (median interval 12 wks.(range 1 to 35)). All patients were assessed by the same experienced cardiologist. Treatment decisions with respect to cabergoline were taken according to the actual guidelines of the German neurological society. Results: In the cross sectional cohort high prevalences for moderate to severe aortic (AR 28.0%), mitral (MR 16.1%) and tricuspidal regurgitation (TR 15.4%) were detected. Severe MR was found in one patient, severe TR in another. Logistic regression analysis revealed arterial hypertension as risk factor for moderate to severe AR (odds ratio 3,74 (1.04-13.45), and cumulative dose, PD duration, and age as risk factors for moderate and severe TR (odds ratios 1.58 (1.09-2.28), 1.17 (1.03-1.33) and 1.14 (1.02-1.28), respectively). In the prospective cohort outcome of AR depended on treatment decision (c2 test; p<0.05), and patients who were discontinued on cabergoline treatment showed significant reductions of AR (Wilcoxon test; p<0.05). Conclusions: Our finding indicate that patients with arterial hypertension are at risk to develop moderate to severe AR. Age and cumulative dose seem to contribute to TR, and discontinuation of cabergoline seems capable to induce a functional remission of AR.
WWW:
https://mediatum.ub.tum.de/?id=807012
Date of submission:
20.08.2009
Oral examination:
08.10.2010
Pages:
138
Urn (citeable URL):
https://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:91-diss-20101008-807012-1-6
Last change:
29.10.2010
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