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Title:

The sweetness of the DNA backbone drives Toll-like receptor 9.

Document type:
Journal Article; Review
Author(s):
Wagner, H
Abstract:
The prevailing paradigm ascribes activation of Toll-like receptor 9 (TLR9) to the detection of CpG-motifs within pathogen derived DNA. However, new work ties natural phospho-diester (PD) DNA recognition by TLR9 to the detection of the DNA sugar backbone 2' deoxyribose. PD 2' deoxyribose homopolymers lacking DNA bases (abasic) are shown to act as TLR9 agonist while abasic phospho-thioate (PS) 2' deoxyribose functions as TLR9 antagonist. Alignment of bases to PD 2' deoxyribose enhanced its TLR9 ag...     »
Journal title abbreviation:
Curr Opin Immunol
Year:
2008
Journal volume:
20
Journal issue:
4
Pages contribution:
396-400
Language:
eng
Fulltext / DOI:
doi:10.1016/j.coi.2008.06.013
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/18656540
Print-ISSN:
0952-7915
TUM Institution:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene
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