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Document type:
Journal Article; Review 
Author(s):
Wagner, H 
Title:
The sweetness of the DNA backbone drives Toll-like receptor 9. 
Abstract:
The prevailing paradigm ascribes activation of Toll-like receptor 9 (TLR9) to the detection of CpG-motifs within pathogen derived DNA. However, new work ties natural phospho-diester (PD) DNA recognition by TLR9 to the detection of the DNA sugar backbone 2' deoxyribose. PD 2' deoxyribose homopolymers lacking DNA bases (abasic) are shown to act as TLR9 agonist while abasic phospho-thioate (PS) 2' deoxyribose functions as TLR9 antagonist. Alignment of bases to PD 2' deoxyribose enhanced its TLR9 ag...    »
 
Journal title abbreviation:
Curr Opin Immunol 
Year:
2008 
Journal volume:
20 
Journal issue:
Pages contribution:
396-400 
Language:
eng 
Print-ISSN:
0952-7915 
TUM Institution:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene