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Titel:

The sweetness of the DNA backbone drives Toll-like receptor 9.

Dokumenttyp:
Journal Article; Review
Autor(en):
Wagner, H
Abstract:
The prevailing paradigm ascribes activation of Toll-like receptor 9 (TLR9) to the detection of CpG-motifs within pathogen derived DNA. However, new work ties natural phospho-diester (PD) DNA recognition by TLR9 to the detection of the DNA sugar backbone 2' deoxyribose. PD 2' deoxyribose homopolymers lacking DNA bases (abasic) are shown to act as TLR9 agonist while abasic phospho-thioate (PS) 2' deoxyribose functions as TLR9 antagonist. Alignment of bases to PD 2' deoxyribose enhanced its TLR9 ag...     »
Zeitschriftentitel:
Curr Opin Immunol
Jahr:
2008
Band / Volume:
20
Heft / Issue:
4
Seitenangaben Beitrag:
396-400
Sprache:
eng
Volltext / DOI:
doi:10.1016/j.coi.2008.06.013
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/18656540
Print-ISSN:
0952-7915
TUM Einrichtung:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene
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