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Titel:

FADD and the NF-kappaB family member Bcl-3 regulate complementary pathways to control T-cell survival and proliferation.

Dokumenttyp:
Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Autor(en):
Rangelova, S; Kirschnek, S; Strasser, A; Häcker, G
Abstract:
Fas-associated protein with death domain/mediator of receptor induced toxicity (FADD/MORT1) was first described as a transducer of death receptor signalling but was later recognized also to be important for proliferation of T cells. B-cell lymphoma 3 (Bcl-3) is a relatively little understood member of the nuclear factor (NF)-kappaB family of transcription factors. We recently found that Bcl-3 is up-regulated in T cells from mice where FADD function is blocked by a dominant negative transgene (FA...     »
Zeitschriftentitel:
Immunology
Jahr:
2008
Band / Volume:
125
Heft / Issue:
4
Seitenangaben Beitrag:
549-57
Sprache:
eng
Volltext / DOI:
doi:10.1111/j.1365-2567.2008.02869.x
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/18557791
Print-ISSN:
0019-2805
TUM Einrichtung:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene
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