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Document type:
Journal Article; Research Support, Non-U.S. Gov't 
Author(s):
Klein, M; Obermaier, B; Angele, B; Pfister, HW; Wagner, H; Koedel, U; Kirschning, CJ 
Title:
Innate immunity to pneumococcal infection of the central nervous system depends on toll-like receptor (TLR) 2 and TLR4. 
Abstract:
BACKGROUND: Recent studies have suggested that, in addition to Toll-like receptor (TLR) 2, other pattern recognition receptors mediate activation of the immune response after infection of the central nervous system (CNS) with Streptococcus pneumoniae (SP). METHODS: Using a mouse meningitis model, we investigated the influence of TLR4 single deficiency (TLR4(-/-)), TLR2/TLR4 double deficiency (TLR2/4(-/-)), and TLR2/TLR4/TLR9 triple deficiency (TLR2/4/9(-/-)) on the immune response of the CNS to...    »
 
Journal title abbreviation:
J Infect Dis 
Year:
2008 
Journal volume:
198 
Journal issue:
Pages contribution:
1028-36 
Language:
eng 
Fulltext / DOI:
Print-ISSN:
0022-1899 
TUM Institution:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene