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Titel:

A cell-based approach to the minimization of immunosuppression in renal transplantation.

Dokumenttyp:
Journal Article; Case Reports; Clinical Trial, Phase II; Clinical Trial, Phase I; Multicenter Study; Research Support, Non-U.S. Gov't
Autor(en):
Hutchinson, JA; Brem-Exner, BG; Riquelme, P; Roelen, D; Schulze, M; Ivens, K; Grabensee, B; Witzke, O; Philipp, T; Renders, L; Humpe, A; Sotnikova, A; Matthäi, M; Heumann, A; Gövert, F; Schulte, T; Kabelitz, D; Claas, FH; Geissler, EK; Kunzendorf, U; Fändrich, F
Abstract:
Five renal transplant recipients were preoperatively treated with transplant acceptance-inducing cells (TAICs) in a Phase-I safety study of TAICs as an adjunct immune-conditioning therapy in living-donor kidney transplantation. Initially, patients received anti-thymocyte globulin induction therapy in combination with tacrolimus and steroid immunosuppression. Over the course of 12 weeks, steroids were withdrawn and tacrolimus therapy was minimized. Three of the five patients were able to tolerate...     »
Zeitschriftentitel:
Transpl Int
Jahr:
2008
Band / Volume:
21
Heft / Issue:
8
Seitenangaben Beitrag:
742-54
Volltext / DOI:
doi:10.1111/j.1432-2277.2008.00692.x
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/18573141
Print-ISSN:
0934-0874
TUM Einrichtung:
Fachgebiet Nephrologie (Prof. Heemann)
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