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Titel:

The octarepeat region of prion protein, but not the TM1 domain, is important for the antioxidant effect of prion protein.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Malaise, M; Schätzl, HM; Bürkle, A
Abstract:
The cellular prion protein (PrP(c)) plays a crucial role in the pathogenesis of prion diseases, but its physiological function is far from understood. Several candidate functions have been proposed including binding and internalization of metal ions, a superoxide dismutase-like activity, regulation of cellular antioxidant activities, and signal transduction. The transmembrane (TM1) region of PrP(c) (residues 110-135) is particularly interesting because of its very high evolutionary conservation....     »
Zeitschriftentitel:
Free Radic Biol Med
Jahr:
2008
Band / Volume:
45
Heft / Issue:
12
Seitenangaben Beitrag:
1622-30
Sprache:
eng
Volltext / DOI:
doi:10.1016/j.freeradbiomed.2008.08.024
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/18824094
Print-ISSN:
0891-5849
TUM Einrichtung:
Institut für Virologie
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