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Titel:

Clusters of hyperactive neurons near amyloid plaques in a mouse model of Alzheimer's disease.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Busche, MA; Eichhoff, G; Adelsberger, H; Abramowski, D; Wiederhold, KH; Haass, C; Staufenbiel, M; Konnerth, A; Garaschuk, O
Abstract:
The neurodegeneration observed in Alzheimer's disease has been associated with synaptic dismantling and progressive decrease in neuronal activity. We tested this hypothesis in vivo by using two-photon Ca2+ imaging in a mouse model of Alzheimer's disease. Although a decrease in neuronal activity was seen in 29% of layer 2/3 cortical neurons, 21% of neurons displayed an unexpected increase in the frequency of spontaneous Ca2+ transients. These "hyperactive" neurons were found exclusively near the...     »
Zeitschriftentitel:
Science
Jahr:
2008
Band / Volume:
321
Heft / Issue:
5896
Seitenangaben Beitrag:
1686-9
Sprache:
eng
Volltext / DOI:
doi:10.1126/science.1162844
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/18802001
Print-ISSN:
0036-8075
TUM Einrichtung:
Institut für Neurowissenschaften
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