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Titel:

Lysosomal activity associated with developmental axon pruning.

Dokumenttyp:
In Vitro; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Autor(en):
Song, JW; Misgeld, T; Kang, H; Knecht, S; Lu, J; Cao, Y; Cotman, SL; Bishop, DL; Lichtman, JW
Abstract:
Clearance of cellular debris is a critical feature of the developing nervous system, as evidenced by the severe neurological consequences of lysosomal storage diseases in children. An important developmental process, which generates considerable cellular debris, is synapse elimination, in which many axonal branches are pruned. The fate of these pruned branches is not known. Here, we investigate the role of lysosomal activity in neurons and glia in the removal of axon branches during early postna...     »
Zeitschriftentitel:
J Neurosci
Jahr:
2008
Band / Volume:
28
Heft / Issue:
36
Seitenangaben Beitrag:
8993-9001
Sprache:
eng
Volltext / DOI:
doi:10.1523/JNEUROSCI.0720-08.2008
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/18768693
Print-ISSN:
0270-6474
TUM Einrichtung:
Institut für Neurowissenschaften
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