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Title:

Lysosomal activity associated with developmental axon pruning.

Document type:
In Vitro; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Author(s):
Song, JW; Misgeld, T; Kang, H; Knecht, S; Lu, J; Cao, Y; Cotman, SL; Bishop, DL; Lichtman, JW
Abstract:
Clearance of cellular debris is a critical feature of the developing nervous system, as evidenced by the severe neurological consequences of lysosomal storage diseases in children. An important developmental process, which generates considerable cellular debris, is synapse elimination, in which many axonal branches are pruned. The fate of these pruned branches is not known. Here, we investigate the role of lysosomal activity in neurons and glia in the removal of axon branches during early postna...     »
Journal title abbreviation:
J Neurosci
Year:
2008
Journal volume:
28
Journal issue:
36
Pages contribution:
8993-9001
Language:
eng
Fulltext / DOI:
doi:10.1523/JNEUROSCI.0720-08.2008
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/18768693
Print-ISSN:
0270-6474
TUM Institution:
Institut für Neurowissenschaften
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