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Title:

TRPC3 channels are required for synaptic transmission and motor coordination.

Document type:
In Vitro; Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't
Author(s):
Hartmann, J; Dragicevic, E; Adelsberger, H; Henning, HA; Sumser, M; Abramowitz, J; Blum, R; Dietrich, A; Freichel, M; Flockerzi, V; Birnbaumer, L; Konnerth, A
Abstract:
In the mammalian central nervous system, slow synaptic excitation involves the activation of metabotropic glutamate receptors (mGluRs). It has been proposed that C1-type transient receptor potential (TRPC1) channels underlie this synaptic excitation, but our analysis of TRPC1-deficient mice does not support this hypothesis. Here, we show unambiguously that it is TRPC3 that is needed for mGluR-dependent synaptic signaling in mouse cerebellar Purkinje cells. TRPC3 is the most abundantly expressed...     »
Journal title abbreviation:
Neuron
Year:
2008
Journal volume:
59
Journal issue:
3
Pages contribution:
392-8
Language:
eng
Fulltext / DOI:
doi:10.1016/j.neuron.2008.06.009
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/18701065
Print-ISSN:
0896-6273
TUM Institution:
Institut für Neurowissenschaften
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