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Titel:

Long-term suppression of hepatitis B virus replication by short hairpin RNA expression using the scaffold/matrix attachment region-based replicating vector system pEPI-1.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Jenke, AC; Wilhelm, AD; Orth, V; Lipps, HJ; Protzer, U; Wirth, S
Abstract:
Since the emergence of viral resistance of hepatitis B virus (HBV) during treatment is becoming an important issue even with newer drugs, there is a need for alternative treatment options such as, for example, RNA interference (RNAi) technology. While short-term suppression of HBV replication is easily achieved with small interfering RNA oligonucleotides, this is not the case for long-term suppression due to the lack of an optimal vector system. Based on the nonviral scaffold/matrix attachment r...     »
Zeitschriftentitel:
Antimicrob Agents Chemother
Jahr:
2008
Band / Volume:
52
Heft / Issue:
7
Seitenangaben Beitrag:
2355-9
Sprache:
eng
Volltext / DOI:
doi:10.1128/AAC.00067-08
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/18474581
Print-ISSN:
0066-4804
TUM Einrichtung:
Institut für Virologie
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