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Titel:

Protective vaccination with hepatitis C virus NS3 but not core antigen in a novel mouse challenge model.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
El-Gogo, S; Staib, C; Lasarte, JJ; Sutter, G; Adler, H
Abstract:
BACKGROUND: Efficient vaccines against hepatitis C virus (HCV) infection are urgently needed. Vaccine development has been hampered by the lack of suitable small animal models to reliably test the protective capacity of immmunization. METHODS: We used recombinant murine gammaherpesvirus 68 (MHV-68) as a novel challenge virus in mice and tested the efficacy of heterologous candidate human vaccines based on modified vaccinia virus Ankara or adenovirus, both delivering HCV non-structural NS3 or cor...     »
Zeitschriftentitel:
J Gene Med
Jahr:
2008
Band / Volume:
10
Heft / Issue:
2
Seitenangaben Beitrag:
177-86
Sprache:
eng
Volltext / DOI:
doi:10.1002/jgm.1144
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/18076128
Print-ISSN:
1099-498X
TUM Einrichtung:
Institut für Virologie
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