Loudness dependence of the auditory evoked N1/P2 component as an indicator of serotonergic dysfunction in patients with schizophrenia--a replication study.

Titel:: Loudness dependence of the auditory evoked N1/P2 component as an indicator of serotonergic dysfunction in patients with schizophrenia--a replication study.
Dokumenttyp:: journal article
Autor(en):: Juckel, G; Gudlowski, Y; Müller, D; Ozgürdal, S; Brüne, M; Gallinat, J; Frodl, T; Witthaus, H; Uhl, I; Wutzler, A; Pogarell, O; Mulert, C; Hegerl, U; Meisenzahl, EM
Abstract:: Serotonergic dysfunction appears to be involved in the pathogenesis of schizophrenia. The loudness dependence of auditory evoked potentials (LDAEP) has been suggested to be a valid indicator of the brain serotonin system's activity in humans. Patients with schizophrenia showed weaker LDAEP, indicating high serotonergic activity, in comparison to healthy controls. Thus, we were able again to demonstrate electrophysiological evidence for an upregulated serotonergic system in schizophrenia.
Zeitschriftentitel:: Psychiatry Res
Jahr:: 2008
Band / Volume:: 158
Heft / Issue:: 1
Seitenangaben Beitrag:: 79-82
Sprache:: eng
PubMed:: http://view.ncbi.nlm.nih.gov/pubmed/18096246
Print-ISSN:: 0165-1781
TUM Einrichtung:: Institut für Radiologie
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