User: Guest  Login
Document type:
In Vitro; Journal Article; Research Support, Non-U.S. Gov't; Article
Author(s):
Weber, S; Bernhard, D; Lukowski, R; Weinmeister, P; Wörner, R; Wegener, JW; Valtcheva, N; Feil, S; Schlossmann, J; Hofmann, F; Feil, R
Title:
Rescue of cGMP kinase I knockout mice by smooth muscle specific expression of either isozyme.
Abstract:
Smooth muscle expresses the Ialpha and the Ibeta isoforms of cGMP-dependent protein kinase I (cGKI). Inactivation of the murine cGKI gene prkg1 leads to multiple phenotypes and premature death at approximately 6 weeks. We reconstituted mice with the cGKIalpha or -Ibeta isozyme to test which isozyme was needed to support basic smooth muscle functions. Mice were generated by gene targeting. The cGKIalpha or the -Ibeta coding sequences were placed under the control of the SM22alpha promoter to expr...    »
Journal title abbreviation:
Circ Res
Year:
2007
Journal volume:
101
Journal issue:
11
Pages contribution:
1096-103
Language:
eng
Fulltext / DOI:
doi:10.1161/CIRCRESAHA.107.154351
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/17901360
Print-ISSN:
0009-7330
TUM Institution:
Institut für Pharmakologie und Toxikologie
 BibTeX