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Journal Article
Jonkers, YM; Claessen, SM; Perren, A; Schmitt, AM; Hofland, LJ; de Herder, W; de Krijger, RR; Verhofstad, AA; Hermus, AR; Kummer, JA; Skogseid, B; Volante, M; Voogd, AC; Ramaekers, FC; Speel, EJ
DNA copy number status is a powerful predictor of poor survival in endocrine pancreatic tumor patients.
The clinical behavior of endocrine pancreatic tumors (EPTs) is difficult to predict in the absence of metastases or invasion to adjacent organs. Several markers have been indicated as potential predictors of metastatic disease, such as tumor size >/=2 cm, Ki67 proliferative index >/=2%, cytokeratin (CK) 19 status, and recently in insulinomas, chromosomal instability (CIN). The goal of this study was to evaluate the value of these markers, and in particular of the CIN, to predict tumor recurrence or progression and tumor-specific death, using a series of 47 insulinomas and 24 non-insulinoma EPTs. From these EPT cases, a genomic profile has been generated and follow-up data have been obtained. The proliferative index has been determined in 68 tumors and a CK19 expression pattern in 50 tumors. Results are statistically analyzed using Kaplan-Meier plots and the log-rank statistic. General CIN, as well as specific chromosomal alterations such as 3p and 6q loss and 12q gain, turned out to be the most powerful indicators for poor tumor-free survival (P/=2% were reliable in predicting a poor tumor-free survival in non-insulinoma EPTs (P
Journal title abbreviation:
Endocr Relat Cancer
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Institut für Allgemeine Pathologie und Pathologische Anatomie