User: Guest  Login
Document type:
Journal Article; Research Support, Non-U.S. Gov't 
Author(s):
Schwartzkopff, S; Gründemann, C; Schweier, O; Rosshart, S; Karjalainen, KE; Becker, KF; Pircher, H 
Title:
Tumor-associated E-cadherin mutations affect binding to the killer cell lectin-like receptor G1 in humans. 
Abstract:
The killer cell lectin-like receptor G1 (KLRG1) is expressed by NK cells and memory T cells in man and mice. Cadherins were recently identified as ligands for mouse KLRG1 but ligands for human KLRG1 have not yet been defined. In this study, we first demonstrate that human E-cadherin is a ligand for human KLRG1. This finding is remarkable because human and mouse KLRG1 show only an intermediate degree of homology (57% aa identity). In addition, we show that E-cadherin, expressed on K562 target cel...    »
 
Journal title abbreviation:
J Immunol 
Year:
2007 
Journal volume:
179 
Journal issue:
Pages contribution:
1022-9 
Language:
eng 
Print-ISSN:
0022-1767 
TUM Institution:
Institut für Allgemeine Pathologie und Pathologische Anatomie