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Document type:
Journal Article
Author(s):
Becker, KF; Schott, C; Hipp, S; Metzger, V; Porschewski, P; Beck, R; Nährig, J; Becker, I; Höfler, H
Title:
Quantitative protein analysis from formalin-fixed tissues: implications for translational clinical research and nanoscale molecular diagnosis.
Abstract:
Owing to its cross-linking effects, it is currently believed that formalin fixation of routinely processed tissues in the clinic prevents protein extraction and profiling. The aim of our study was to develop a robust, fast, standardized, and easy to use technique for the solubilization of non-degraded, full length, and immunoreactive proteins from formalin-fixed tissues for western blot and protein microarray analysis. Sections of routinely processed formalin-fixed and paraffin-embedded tissues...    »
Journal title abbreviation:
J Pathol
Year:
2007
Journal volume:
211
Journal issue:
3
Pages contribution:
370-8
Language:
eng
Fulltext / DOI:
doi:10.1002/path.2107
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/17133373
Print-ISSN:
0022-3417
TUM Institution:
Institut für Allgemeine Pathologie und Pathologische Anatomie
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