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- Title:
Imaging axonal transport of mitochondria in vivo.
- Document type:
- Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Article
- Author(s):
- Misgeld, T; Kerschensteiner, M; Bareyre, FM; Burgess, RW; Lichtman, JW
- Abstract:
- Neuronal mitochondria regulate synaptic physiology and cellular survival, and disruption of their function or transport causes neurological disease. We present a fluorescence method to selectively image mitochondrial dynamics in the mouse nervous system, in both live mice and acute explants. We show that axon damage and recovery lead to early and sustained changes in anterograde and retrograde transport. In vivo imaging of mitochondria will be a useful tool to analyze this essential organelle.
- Journal title abbreviation:
- Nat Methods
- Year:
- 2007
- Journal volume:
- 4
- Journal issue:
- 7
- Pages contribution:
- 559-61
- Language:
- eng
- Fulltext / DOI:
- doi:10.1038/nmeth1055
- Pubmed ID:
- http://view.ncbi.nlm.nih.gov/pubmed/17558414
- Print-ISSN:
- 1548-7091
- TUM Institution:
- Institut für Neurowissenschaften
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