User: Guest  Login
Title:

Early MRI changes in a mouse model of multiple sclerosis are predictive of severe inflammatory tissue damage.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Nessler, S; Boretius, S; Stadelmann, C; Bittner, A; Merkler, D; Hartung, HP; Michaelis, T; Brück, W; Frahm, J; Sommer, N; Hemmer, B
Abstract:
MRI is routinely used for in vivo detection of multiple sclerosis (MS) lesions. Histopathological correlates of MRI signal alterations are still poorly defined. In the present study, we describe a mouse model of MS presenting with inflammatory brain lesions. During the acute disease phase, two independent lesion patterns were identified by T1- and T2-weighted high-resolution 3D MRI: lesions with reduced signal intensity on both T1- and T2-weighted images (type A) and lesions with slightly reduce...     »
Journal title abbreviation:
Brain
Year:
2007
Journal volume:
130
Journal issue:
Pt 8
Pages contribution:
2186-98
Language:
eng
Fulltext / DOI:
doi:10.1093/brain/awm105
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/17617655
Print-ISSN:
0006-8950
TUM Institution:
Neurologische Klinik und Poliklinik
 BibTeX