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Title:

Acute brain injury triggers MyD88-dependent, TLR2/4-independent inflammatory responses.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Koedel, U; Merbt, UM; Schmidt, C; Angele, B; Popp, B; Wagner, H; Pfister, HW; Kirschning, CJ
Abstract:
Endogenous molecules released from disrupted cells and extracellular matrix degradation products activate Toll-like receptors (TLRs) and, thus, might contribute to immune activation after tissue injury. Here, we show that aseptic, cold-induced cortical injury triggered an acute immune response that involves increased production of multiple cytokines/chemokines accompanied by neutrophil recruitment to the lesion site. We observed selective reductions in injury-induced cytokine/chemokine expressio...     »
Journal title abbreviation:
Am J Pathol
Year:
2007
Journal volume:
171
Journal issue:
1
Pages contribution:
200-13
Language:
eng
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/17591966
Print-ISSN:
0002-9440
TUM Institution:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene
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