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Document type:
Journal Article; Research Support, Non-U.S. Gov't; Article
Author(s):
Schulz, C; Schafer, A; Stolla, M; Kerstan, S; Lorenz, M; von Brühl, ML; Schiemann, M; Bauersachs, J; Gloe, T; Busch, DH; Gawaz, M; Massberg, S
Title:
Chemokine fractalkine mediates leukocyte recruitment to inflammatory endothelial cells in flowing whole blood: a critical role for P-selectin expressed on activated platelets.
Abstract:
BACKGROUND: The membrane-bound chemokine fractalkine (CX3CL1) is expressed on various cell types such as activated endothelial cells and has been implicated in the inflammatory process of atherosclerosis. The aim of the present study was to dissect the role of fractalkine in leukocyte recruitment to inflamed endothelium under arterial shear forces. METHODS AND RESULTS: With the use of immunofluorescence and laminar flow assays, the present study shows that human umbilical vein endothelial cells...    »
Journal title abbreviation:
Circulation
Year:
2007
Journal volume:
116
Journal issue:
7
Pages contribution:
764-73
Language:
eng
Fulltext / DOI:
doi:10.1161/CIRCULATIONAHA.107.695189
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/17679613
Print-ISSN:
0009-7322
TUM Institution:
I. Medizinische Klinik und Poliklinik (Kardiologie); Institut für Medizinische Mikrobiologie, Immunologie und Hygiene
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