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Document type:
Journal Article; Article
Author(s):
Ueblacker, P; Wagner, B; Vogt, S; Salzmann, G; Wexel, G; Kruger, A; Plank, C; Brill, T; Specht, K; Hennig, T; Schillinger, U; Imhoff, AB; Martinek, V; Gansbacher, B
Title:
In vivo analysis of retroviral gene transfer to chondrocytes within collagen scaffolds for the treatment of osteochondral defects.
Abstract:
To examine a retroviral gene transfer to chondrocytes in vitro and in vivo in tissue-engineered cell-collagen constructs articular chondrocytes from rabbits and humans were isolated and transduced with VSV.G pseudotyped murine leukemia virus-derived retroviral vectors. Viral supernatants were generated by transient transfection of 293T cells using the pBullet retroviral vector carrying the nlslacZ gene, a Moloney murine leukemia virus gag/pol plasmid and a VSV.G coding plasmid. Transduction effi...    »
Journal title abbreviation:
Biomaterials
Year:
2007
Journal volume:
28
Journal issue:
30
Pages contribution:
4480-7
Language:
eng
Fulltext / DOI:
doi:10.1016/j.biomaterials.2007.06.027
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/17629939
Print-ISSN:
0142-9612
TUM Institution:
Fachgebiet Sportorthopädie (Prof. Imhoff); Institut für Experimentelle Onkologie und Therapieforschung
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