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Titel:

NK cell activation in visceral leishmaniasis requires TLR9, myeloid DCs, and IL-12, but is independent of plasmacytoid DCs.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't; Article
Autor(en):
Schleicher, U; Liese, J; Knippertz, I; Kurzmann, C; Hesse, A; Heit, A; Fischer, JA; Weiss, S; Kalinke, U; Kunz, S; Bogdan, C
Abstract:
Natural killer (NK) cells are sentinel components of the innate response to pathogens, but the cell types, pathogen recognition receptors, and cytokines required for their activation in vivo are poorly defined. Here, we investigated the role of plasmacytoid dendritic cells (pDCs), myeloid DCs (mDCs), Toll-like receptors (TLRs), and of NK cell stimulatory cytokines for the induction of an NK cell response to the protozoan parasite Leishmania infantum. In vitro, pDCs did not endocytose Leishmania...     »
Zeitschriftentitel:
J Exp Med
Jahr:
2007
Band / Volume:
204
Heft / Issue:
4
Seitenangaben Beitrag:
893-906
Sprache:
eng
Volltext / DOI:
doi:10.1084/jem.20061293
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/17389237
Print-ISSN:
0022-1007
TUM Einrichtung:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene
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