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Title:

Interdependency of MHC class II/self-peptide and CD1d/self-glycolipid presentation by TNF-matured dendritic cells for protection from autoimmunity.

Document type:
Journal Article; Research Support, Non-U.S. Gov't; Article
Author(s):
Wiethe, C; Schiemann, M; Busch, D; Haeberle, L; Kopf, M; Schuler, G; Lutz, MB
Abstract:
Dendritic cells (DC) are key regulators of T cell immunity and tolerance. NKT cells are well-known enhancers of Th differentiation and regulatory T cell function. However, the nature of the DC directing T and NKT cell activation and polarization as well as the role of the respective CD1d Ags presented is still unclear. In this study, we show that peptide-specific CD4(+)IL-10(+) T cell-mediated full experimental autoimmune encephalomyelitis (EAE) protection by TNF-treated semimatured DCs was depe...     »
Journal title abbreviation:
J Immunol
Year:
2007
Journal volume:
178
Journal issue:
8
Pages contribution:
4908-16
Language:
eng
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/17404272
Print-ISSN:
0022-1767
TUM Institution:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene
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