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Titel:

Small poly-L-lysines improve cationic lipid-mediated gene transfer in vascular cells in vitro and in vivo.

Dokumenttyp:
In Vitro; Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Golda, A; Pelisek, J; Klocke, R; Engelmann, MG; Rolland, PH; Mekkaoui, C; Nikol, S
Abstract:
The potential of two small poly-L-lysines (sPLLs), low molecular weight sPLL (LMW-L) containing 7-30 lysine residues and L18 with 18 lysine repeats, to enhance the efficiency of liposome-mediated gene transfer (GT) with cationic lipid DOCSPER [1,3-dioleoyloxy-2-(N(5)-carbamoyl-spermine)-propane] in vascular smooth muscle cells (SMCs) was investigated. Dynamic light scattering was used for determination of particle size. Confocal microscopy was applied for colocalization studies of sPLLs and plas...     »
Zeitschriftentitel:
J Vasc Res
Jahr:
2007
Band / Volume:
44
Heft / Issue:
4
Seitenangaben Beitrag:
273-82
Sprache:
eng
Volltext / DOI:
doi:10.1159/000101449
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/17406119
Print-ISSN:
1018-1172
TUM Einrichtung:
Fachgebiet Gefäßchirurgie (Prof. Eckstein)
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