Longitudinal quantitative assessment of coronary atherosclerosis related to normal systolic blood pressure maintenance in the absence of established cardiovascular disease.

Won, Ki-Bum; Park, Hyung-Bok; Heo, Ran; Lee, Byoung Kwon; Lin, Fay Y; Hadamitzky, Martin; Kim, Yong-Jin; Sung, Ji Min; Conte, Edoardo; Andreini, Daniele; Pontone, Gianluca; Budoff, Matthew J; Gottlieb, Ilan; Chun, Eun Ju; Cademartiri, Filippo; Maffei, Erica; Marques, Hugo; Gonçalves, Pedro de Araújo; Leipsic, Jonathon A; Lee, Sang-Eun; Shin, Sanghoon; Choi, Jung Hyun; Virmani, Renu; Samady, Habib; Chinnaiyan, Kavitha; Berman, Daniel S; Narula, Jagat; Bax, Jeroen J; Min, James K; Chang, Hyuk-Jae

doi:10.1002/clc.23870

Institut für Radiologie und Nuklearmedizin

Back
Back to start of result list
Permanent link for displayed object

Title:: Longitudinal quantitative assessment of coronary atherosclerosis related to normal systolic blood pressure maintenance in the absence of established cardiovascular disease.
Document type:: Journal Article
Author(s):: Won, Ki-Bum; Park, Hyung-Bok; Heo, Ran; Lee, Byoung Kwon; Lin, Fay Y; Hadamitzky, Martin; Kim, Yong-Jin; Sung, Ji Min; Conte, Edoardo; Andreini, Daniele; Pontone, Gianluca; Budoff, Matthew J; Gottlieb, Ilan; Chun, Eun Ju; Cademartiri, Filippo; Maffei, Erica; Marques, Hugo; Gonçalves, Pedro de Araújo; Leipsic, Jonathon A; Lee, Sang-Eun; Shin, Sanghoon; Choi, Jung Hyun; Virmani, Renu; Samady, Habib; Chinnaiyan, Kavitha; Berman, Daniel S; Narula, Jagat; Bax, Jeroen J; Min, James K; Chang, Hyuk-Jae
Abstract:: BACKGROUND: Atherosclerosis-related adverse events are commonly observed even in conditions with low cardiovascular (CV) risk. Longitudinal data regarding the association of normal systolic blood pressure maintenance (SBPmaintain ) with coronary plaque volume changes (PVC) has been limited in adults without traditional CV disease. HYPOTHESIS: Normal SBPmaintain is important to attenuate coronary atherosclerosis progression in adults without baseline CV disease. METHODS: We analyzed 95 adults (56.7 ± 8.5 years; 40.0% men) without baseline CV disease who underwent serial coronary computed tomographic angiography with mean 3.5 years of follow-up. All participants were divided into two groups of normal SBPmaintain (follow-up SBP < 120 mm Hg) and ≥elevated SBPmaintain (follow-up SBP ≥ 120 mm Hg). Annualized PVC was defined as PVC divided by the interscan period. RESULTS: Compared to participants with normal SBPmaintain , those with ≥elevated SBPmaintain had higher annualized total PVC (mm3 /year) (0.0 [0.0-2.2] vs. 4.1 [0.0-13.0]; p < .001). Baseline total plaque volume (β = .10) and the levels of SBPmaintain (β = .23) and follow-up high-density lipoprotein cholesterol (β = -0.28) were associated with annualized total PVC (all p < .05). The optimal cutoff of SBPmaintain for predicting plaque progression was 118.5 mm Hg (sensitivity: 78.2%, specificity: 62.5%; area under curve: 0.700; 95% confidence interval [CI]: 0.59-0.81; p < .05). SBPmaintain ≥ 118.5 mm Hg (odds ratio [OR]: 4.03; 95% CI: 1.51-10.75) and baseline total plaque volume (OR: 1.03; 95% CI: 1.01-1.06) independently influenced coronary plaque progression (all p < .05). CONCLUSION: Normal SBPmaintain is substantial to attenuate coronary atherosclerosis progression in conditions without established CV disease.
Journal title abbreviation:: Clin Cardiol
Year:: 2022
Journal volume:: 45
Journal issue:: 8
Pages contribution:: 873-881
Fulltext / DOI:: doi:10.1002/clc.23870
Pubmed ID:: http://view.ncbi.nlm.nih.gov/pubmed/35673995
Print-ISSN:: 0160-9289
TUM Institution:: Institut für Radiologie und Nuklearmedizin
BibTeX

Occurrences:

mediaTUM Gesamtbestand Hochschulbibliographie 2022 Schools und Fakultäten Medizin Institut für Radiologie

mediaTUM Gesamtbestand Einrichtungen Schools TUM School of Medicine and Health Departments Clinical Medicine Institut für Diagnostische und Interventionelle Radiologie (Prof. Makowski)Institut für Radiologie und Nuklearmedizin 2022