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Title:

Interferon-regulatory-factor 1 controls Toll-like receptor 9-mediated IFN-beta production in myeloid dendritic cells.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Schmitz, F; Heit, A; Guggemoos, S; Krug, A; Mages, J; Schiemann, M; Adler, H; Drexler, I; Haas, T; Lang, R; Wagner, H
Abstract:
Activation of interferon regulatory factor (IRF)-3 and/or IRF-7 drives the expression of antiviral genes and the production of alpha/beta IFN, a hallmark of antiviral responses triggered by Toll-like receptors (TLR). Here we describe a novel antiviral signaling pathway operating in myeloid (m) dendritic cells (DC) and macrophages that does not require IRF-3 and/or IRF-7 but is driven by IRF-1. IRF-1 together with myeloid differentiation factor 88 (MyD88) or IL-1 receptor-associated kinase (IRAK)...     »
Journal title abbreviation:
Eur J Immunol
Year:
2007
Journal volume:
37
Journal issue:
2
Pages contribution:
315-27
Language:
eng
Fulltext / DOI:
doi:10.1002/eji.200636767
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/17273999
Print-ISSN:
0014-2980
TUM Institution:
II. Medizinische Klinik und Poliklinik (Gastroenterologie); Institut für Medizinische Mikrobiologie, Immunologie und Hygiene; Institut für Virologie
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