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Title:

Immunogenicity of a silica nanoparticle-based SARS-CoV-2 vaccine in mice.

Document type:
Journal Article
Author(s):
Barbey, Clara; Su, Jinpeng; Billmeier, Martina; Stefan, Nadine; Bester, Romina; Carnell, George; Temperton, Nigel; Heeney, Jonathan; Protzer, Ulrike; Breunig, Miriam; Wagner, Ralf; Peterhoff, David
Abstract:
Safe and effective vaccines have been regarded early on as critical in combating the COVID-19 pandemic. Among the deployed vaccine platforms, subunit vaccines have a particularly good safety profile but may suffer from a lower immunogenicity compared to mRNA based or viral vector vaccines. In fact, this phenomenon has also been observed for SARS-CoV-2 subunit vaccines comprising the receptor-binding domain (RBD) of the spike (S) protein. Therefore, RBD-based vaccines have to rely on additional m...     »
Journal title abbreviation:
Eur J Pharm Biopharm
Year:
2023
Journal volume:
192
Pages contribution:
41-55
Fulltext / DOI:
doi:10.1016/j.ejpb.2023.09.015
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/37774890
Print-ISSN:
0939-6411
TUM Institution:
Institut für Virologie (Prof. Protzer)
 BibTeX