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Titel:

Copper impairs the intestinal barrier integrity in Wilson disease.

Dokumenttyp:
Journal Article
Autor(en):
Fontes, Adriana; Pierson, Hannah; Bierła, Joanna B; Eberhagen, Carola; Kinschel, Jennifer; Akdogan, Banu; Rieder, Tamara; Sailer, Judith; Reinold, Quirin; Cielecka-Kuszyk, Joanna; Szymańska, Sylwia; Neff, Frauke; Steiger, Katja; Seelbach, Olga; Zibert, Andree; Schmidt, Hartmut H; Hauck, Stefanie M; von Toerne, Christine; Michalke, Bernhard; Semrau, Jeremy D; DiSpirito, Ana M; Ramalho-Santos, João; Kroemer, Guido; Polishchuk, Roman; Azul, Anabela Marisa; DiSpirito, Alan; Socha, Piotr; Lutsenko, S...     »
Abstract:
In Wilson disease (WD), liver copper (Cu) excess, caused by mutations in the ATPase Cu transporting beta (ATP7B), has been extensively studied. In contrast, in the gastrointestinal tract, responsible for dietary Cu uptake, ATP7B malfunction is poorly explored. We therefore investigated gut biopsies from WD patients and compared intestines from two rodent WD models and from human ATP7B knock-out intestinal cells to their respective wild-type controls. We observed gastrointestinal (GI) inflammatio...     »
Zeitschriftentitel:
Metabolism
Jahr:
2024
Band / Volume:
158
Volltext / DOI:
doi:10.1016/j.metabol.2024.155973
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/38986805
Print-ISSN:
0026-0495
TUM Einrichtung:
Institut für Toxikologie und Umwelthygiene (Prof. Göttlicher)
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